我国地表水和沉积物PPCPs赋存与交互迁移影响因素

田永静; 武宇圣; 黄天寅; 陈书琴; 张家根; 庞燕

doi:10.12153/j.issn.1674-991X.20220418

我国地表水和沉积物PPCPs赋存与交互迁移影响因素

doi: 10.12153/j.issn.1674-991X.20220418

田永静^1,,
武宇圣^{1, 2, 3},
黄天寅¹,
陈书琴⁴,
张家根^{1, 2, 3},
庞燕^{2, 3, ,}

1.
苏州科技大学环境科学与工程学院
2.
湖泊水污染治理与生态修复技术国家工程实验室, 中国环境科学研究院
3.
国家环境保护湖泊污染控制重点实验室, 中国环境科学研究院
4.
安庆师范大学资源环境学院

基金项目: 国家水体污染控制与治理科技重大专项(2017ZX07301-006-06)

详细信息

作者简介:
田永静（1969—），女，副教授，主要从事水污染控制工程研究，t12612618@163.com

通讯作者:
庞燕（1970—），女，研究员，主要从事湖泊水污染控制及生态修复研究，190068749@qq.com

中图分类号: X52
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出版历程
- 收稿日期: 2022-05-02

Occurrence of PPCPs in surface water and sediment in China and influencing factors of interactive migration

TIAN Yongjing^1
,,
WU Yusheng^{1, 2, 3},
HUANG Tianyin¹,
CHEN Shuqin⁴,
ZHANG Jiagen^{1, 2, 3},
PANG Yan^{2, 3
, ,}

1.
School of Environmental Science and Engineering, Suzhou University of Science and Technology
2.
National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, Chinese Research Academy of Environmental Sciences
3.
State Environmental Protection Key Laboratory for Lake Pollution Control, Chinese Research Academy of Environmental Sciences
4.
Resource and Environment College of Anqing Normal University

摘要

摘要:
药品及个人护理品（PPCPs）作为一类典型的新型污染物，由于被广泛使用和存在“假持久性”，在水环境中经常被检测到，引起全球的广泛关注。沉积物是PPCPs重要的环境蓄积库，被污染的沉积物可成为长期污染源对上覆水造成污染。综述了近年来国内外研究成果，分析了PPCPs在中国七大地区典型地表水和沉积物中的赋存现状，归纳总结了PPCPs自身性质、沉积物组分和环境因素对PPCPs在水-沉积物体系交互迁移的影响。结果表明：1）我国地表水中检测到的PPCPs浓度为未检出（ND）~9 785 ng/L，检出率和浓度较高的PPCPs有20种，浓度最高的为非抗生素类药物的咖啡因（CAF），其次为红霉素（ETM）和磺胺甲噁唑（SMX）。我国七大地区地表水中浓度最高的PPCPs是非抗生素类药物兴奋剂，其在华北、华南、西南和西北地区污染程度较高；其次是抗生素类药物中的大环内酯类和磺胺类，其在东北、华东和华中地区污染程度较高。华北地区地表水中PPCPs污染程度最高，其次为华东地区。2）我国水体沉积物中检测到的PPCPs浓度为ND~3 440 ng/g，检出率和浓度较高的PPCPs有18种，其中浓度最高的是三氯卡班（TCC），其次是土霉素（OTC）和诺氟沙星（NOR）。我国七大地区沉积物中浓度最高的PPCPs是个人护理品抗菌剂，其在华南地区污染程度最高；其次是四环素类和喹诺酮类，其中四环素类在华东、华中和东北地区污染程度较高，喹诺酮类在华北、西北和西南地区污染程度较高。华南地区沉积物中PPCPs污染程度最高，其次为华东地区。3）我国地表水和沉积物中PPCPs浓度在世界范围内处于较高水平。水-沉积物体系的交互迁移主要受PPCPs自身性质和沉积物组分的影响，需要进一步明确沉积物组分和水环境条件等多因素耦合作用下的PPCPs交互迁移机制。
- 药品及个人护理品（PPCPs） /
- 地表水 /
- 沉积物 /
- 抗生素 /
- 交互迁移 /
- 七大地区
Abstract:
Pharmaceuticals and personal care products (PPCPs), as a class of typical new pollutants, are often detected in the water environment due to their widespread use and pseudo-persistence, which has aroused worldwide attention. Sediments are important environmental repositories of PPCPs, and polluted sediments can be regarded as long-term pollution sources to cause the pollution of the overlying water. The research results at home and abroad in recent years were reviewed, the occurrence of PPCPs in typical surface water and sediment in seven regions of China were analyzed, and the effects of PPCPs characteristics, sediment components and environmental factors on the interaction migration of PPCPs in water-sediment system were summarized. The results showed as follows:1) The concentration of PPCPs detected in surface water in China ranged from undetected (ND) to 9 785 ng/L. There were 20 kinds of PPCPs with high detection rates and concentrations. The highest concentration was with caffeine (CAF), a non-antibiotic drug, followed by erythromycin (ETM) and sulfamethoxazole (SMX). PPCPs with the highest pollution concentration in the surface water of seven regions of China were non-antibiotic stimulants, which were highly polluted in North China, South China, and Southwest and Northwest, followed by macrolides and sulfonamides in antibiotics which were highly polluted in Northeast, East China and Central China. The highest level of PPCPs pollution in surface water was found in North China, followed by East China. 2) The concentration of PPCPs detected in sediments in China was ND-3 440 ng/g. There were 18 kinds of PPCPs with high detection rates and concentrations, among which triclocarban (TCC) had the highest concentration, followed by oxytetracycline (OTC) and norfloxacin (NOR). PPCPs with the highest pollution concentration in the sediments of seven regions of China were personal care antibacterial agents, with the highest pollution degree in South China, followed by tetracycline and quinolones. Tetracycline pollution degree was higher in East China, Central China and Northeast, and quinolones pollution degree was higher in north China, Northwest and Southwest. The pollution degree of PPCPs in sediments in South China was the highest, followed by East China. 3) PPCPs concentrations in surface water and sediments in China were at a higher level worldwide. The interaction migration of water-sediment system was mainly affected by the nature of PPCPs and sediment components, and the interaction migration mechanism of PPCPs under the coupling effect of sediment components and water environment conditions needed to be further clarified.
- pharmaceuticals and personal care products (PPCPs) /
- surface water /
- sediment /
- antibiotic /
- interactive migration /
- seven regions ofChina

HTML全文

图 1 我国七大地区地表水中主要赋存的PPCPs及检测到的最高浓度^{[16-21,24-29,31-43,54]}

Figure 1. Main PPCPs and the highest concentrations detected in surface water from seven regions of China

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图 2 我国七大地区地表水体沉积物中主要赋存的PPCPs及检测到的最高浓度^{[17,21,25-26,29-30,34-37,40,43-44,58-62,64]}

Figure 2. Main PPCPs and the highest concentrations detected in sediments from surface water bodies of seven regions of China

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表 1 我国七大地区地表水中易检测到的20种PPCPs及其浓度

Table 1. 20 kinds of PPCPs and their concentrations in surface water from seven regions of China

PPCPs类别		污染物名称	使用类型	浓度/（ng/L）	数据来源
抗生素类药物	磺胺类（SAs）	磺胺甲噁唑（SMX）	人兽共用	ND~1 830.2	文献[16-44]
		磺胺甲嘧啶（SMZ）	人兽共用	ND~654.0	文献[16-21,24-33,36-38]
		磺胺嘧啶（SDZ）	人兽共用	ND~520	文献[16-21,24-33,36-38]
		甲氧苄啶（TMP）	人用	ND~976.10	文献[16-21,24-33,36-38]
	喹诺酮类 (QNs)	诺氟沙星（NOR）	人兽共用	ND~403	文献[16-44]
		氧氟沙星（OFL）	人兽共用	ND~632.52	文献[16-44]
		环丙沙星（CIP）	人用	ND~414	文献[16-44]
	四环素类 (TCs)	四环素（TC）	人兽共用	ND~250.37	文献[16-44]
	四环素类 (TCs)	土霉素（OTC）	人兽共用	ND~321	文献[16-44]
	大环内酯类 (MLs)	红霉素（ETM）	人兽共用	ND~2 834.6	文献[16-44]
	大环内酯类 (MLs)	罗红霉素（ROX）	人用	ND~740.99	文献[16-21,24-33,36-38,42,44]
	其他类	林可霉素(LIN)	人兽共用	ND~407.12	文献[16-21,24-33,36-38]
非抗生素类药物	非甾体抗炎药	双氯芬酸（DIC）	人用	ND~645	文献[16-21,24-33,36-38,41-44]
		布洛芬（IBU）	人用	ND~362	文献[16-21,24-33,36-38,41-44]
		对乙酰氨基酚（ATP）	人用	ND~960	文献[16-21,24-33,36-38,41-44]
	抗癫痫药	卡马西平（CBZ）	人用	ND~271.02	文献[16-21,24-33,36-38,41-44]
	兴奋剂	咖啡因（CAF）	人用	ND~9 785	文献[16-21,24-33,36-38, 41-44]
个人护理品	抗菌剂	三氯生（TCS）	人用	ND~282	文献[16-21,24-33,36-38,41-44]
	抗菌剂	三氯卡班（TCC）	人用	ND~210	文献[16-21,24-33,36-38,41-44]
	杀虫剂	避蚊胺（DEET）	兽用	ND~574.75	文献[16-21,24-33,36-38,41-44]
注：ND为未检出。

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表 2 我国七大地区水体沉积物中易检测到的18种PPCPs及其浓度

Table 2. 18 kinds of PPCPs and their concentrations in sediments from seven regions of China

PPCPs类别		污染物名称	使用类型	浓度/（ng/g）	数据来源
抗生素类药物	磺胺类（SAs）	磺胺甲噁唑（SMX）	人兽共用	ND~688.59	文献[17,21,25-26,29-30,34-36,40,43-44,58-64]
		磺胺甲嘧啶（SMZ）	人兽共用	ND~122.29	文献[17,21,25-26,29-30]
		甲氧苄啶（TMP）	人用	ND~103	文献[17,21,25-26,29-30,34-36]
	喹诺酮类 (QNs)	诺氟沙星（NOR）	人兽共用	ND~1 140	文献[17,21,25-26,29-30,34-36,40,43-44,58-64]
		氧氟沙星（OFL）	人兽共用	ND~452	文献[17,21,25-26,29-30,34-36]
		环丙沙星（CIP）	人用	ND~449	文献[17,21,25-26,29-30,34-36]
	四环素类 (TCs)	四环素（TC）	人兽共用	ND~635	文献[17,21,25,26,29-30,34-36,40,43,44,58-64]
	四环素类 (TCs)	土霉素（OTC）	人兽共用	ND~1 290	文献[17,21,25-26,29-30,34-36,40,43-44,58-64]
	大环内酯类 (MLs)	红霉素（ETM）	人兽共用	ND~175.38	文献[17,21,25-26,29-30,34-36,40,43-44,58-64]
	大环内酯类 (MLs)	罗红霉素（ROM）	人用	ND~302	文献[17,21,25-26,29-30, 34-36]
	其他类	林可霉素（LIN）	人兽共用	ND~47.8	文献[17,21,25-26,29-30]
非抗生素类药物	非甾体抗炎药	双氯芬酸（DIC）	人用	ND~278.1	文献[17,21,25-26,29-30, 34-37]
		布洛芬（IBU）	人用	ND~227.1	文献[17,21,25-26,29-30,34-37]
		对乙酰氨基酚（ATP）	人用	ND~320.7	文献[17,21,25-26,29-30,34-37]
	抗癫痫药	卡马西平（CBZ）	人用	ND~54.2	文献[17,21,25-26,29-30,34-37]
	兴奋剂	咖啡因（CAF）	人用	ND~482	文献[17,21,25-26,29-30,34-37]
个人护理品	抗菌剂	三氯生（TCS）	人用	ND~689	文献[17,21,25-26,29-30,34-37]
个人护理品	抗菌剂	三氯卡班（TCC）	人用	ND~3 440	文献[17,21,25-26,29-30,34-37]
注：ND为未检出。

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表 3 PPCPs在水-沉积物体系的分配系数

Table 3. Distribution coefficient of PPCPs in water-sediment system

地区	PPCPs类型	污染物名称	K_d/(L/kg)
太湖^[61]	大环内酯类(MLs)	阿奇霉素（AZM）	72.0
	非抗生素类药物	对乙酰氨基酚（ATP）	0.435
		地尔硫卓（DIL）	12.3
		卡马西平（CBZ）	7.35
		咖啡因（CAF）	0.201
上海青浦区水环境^[29]	非抗生素类药物	酮洛芬（KPF）	2.86
上海青浦区水环境^[29]	个人护理品	三氯卡班（TCC）	5.61
围场县水体^[77]	磺胺类(SAs)	磺胺甲噁唑（SMX）	2.88
	四环素类(TCs)	土霉素（OTC）	2 162.2
	喹诺酮类(QNs)	氧氟沙星（NOR）	926.6
	大环内酯类(MLs)	罗红霉素（ROM）	4.00
	非抗生素类药物	咖啡因（CAF）	1.43
南海海陵湾^[78]	四环素类(TCs)	四环素（TC）	1 608
南海海陵湾^[78]	大环内酯类(MLs)	红霉素（ETM）	359
黄河三角洲^[79]	四环素类(TCs)	四环素（TC）	765.93
黄河三角洲^[79]	大环内酯类(MLs)	红霉素（ETM）	230.14

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参考文献(100)

[1]	DAUGHTON C G, TERNES T A. Pharmaceuticals and personal care products in the environment: agents of subtle change[J]. Environmental Health Perspectives,1999,107(Suppl 6):907-938. doi: 10.1289/ehp.99107s6907
[2]	DEY S, BANO F, MALIK A. Pharmaceuticals and personal care product (PPCP) contamination:a global discharge inventory[M]//Pharmaceuticals and personal care products: waste management and treatment technology. Amsterdam: Elsevier, 2019: 1-26.
[3]	La FARRÉ M, PÉREZ S, KANTIANI L, et al. Fate and toxicity of emerging pollutants, their metabolites and transformation products in the aquatic environment[J]. TrAC Trends in Analytical Chemistry,2008,27(11):991-1007. doi: 10.1016/j.trac.2008.09.010
[4]	李松旌, 樊向阳, 崔二苹, 等.PPCPs在土壤-作物系统行为特征及环境风险的研究进展[J]. 化工进展,2021,40(5):2827-2838. LI S J, FAN X Y, CUI E P, et al. Advances in behavioral characteristics and environmental risks of PPCPs in soil-crop systems[J]. Chemical Industry and Engineering Progress,2021,40(5):2827-2838.
[5]	韦巧珍, 林子雨.PPCPs的环境暴露、毒性效应及风险评估研究进展[J]. 环境科学与技术,2020,43(4):16-24. WEI Q Z, LIN Z Y. Research progress in environmental exposure, toxic effect and risk assessment of pharmaceuticals and personal care products[J]. Environmental Science & Technology,2020,43(4):16-24.
[6]	申立娜, 付雨, 张璐璐, 等.白洋淀优势鱼类中喹诺酮类抗生素的生物累积特征及其与环境因子相关性[J]. 环境科学,2020,41(12):5470-5479. SHEN L N, FU Y, ZHANG L L, et al. Bioaccumulation characteristics of quinolones (QNs) in dominant fish species and their correlation with environmental factors in Baiyangdian Lake[J]. Environmental Science,2020,41(12):5470-5479.
[7]	ZHOU J, ZENG X Y, ZHENG K W, et al. Musks and organochlorine pesticides in breast milk from Shanghai, China: levels, temporal trends and exposure assessment[J]. Ecotoxicology and Environmental Safety,2012,84:325-333. doi: 10.1016/j.ecoenv.2012.08.011
[8]	OHORO C R, ADENIJI A O, OKOH A I, et al. Distribution and chemical analysis of pharmaceuticals and personal care products (PPCPs) in the environmental systems: a review[J]. International Journal of Environmental Research and Public Health,2019,16(17):3026. doi: 10.3390/ijerph16173026
[9]	李欣, 纪道斌, 宋林旭, 等.香溪河沉积物-水界面的营养盐交换特征[J]. 环境科学研究,2017,30(8):1212-1220. LI X, JI D B, SONG L X, et al. Characteristics of nutrient exchange at the sediment-water interface in Xiangxi Bay[J]. Research of Environmental Sciences,2017,30(8):1212-1220.
[10]	张雨笛. 再悬浮扰动下巢湖水-沉积物界面重金属的释放[D].合肥: 合肥工业大学, 2021.
[11]	XIANG Y, WU H H, LI L, et al. A review of distribution and risk of pharmaceuticals and personal care products in the aquatic environment in China[J]. Ecotoxicology and Environmental Safety,2021,213:112044. doi: 10.1016/j.ecoenv.2021.112044
[12]	WANG H, XI H, XU L L, et al. Ecotoxicological effects, environmental fate and risks of pharmaceutical and personal care products in the water environment: a review[J]. Science of the Total Environment,2021,788:147819. doi: 10.1016/j.scitotenv.2021.147819
[13]	SHI X, REN B, JIN X, et al. Metabolic hazards of pharmaceuticals and personal care products (PPCPs) in sewers[J]. Journal of Hazardous Materials,2022,432:128539. doi: 10.1016/j.jhazmat.2022.128539
[14]	WANG Y Q, HU L X, ZHAO J H, et al. Suspect, non-target and target screening of pharmaceuticals and personal care products (PPCPs) in a drinking water system[J]. Science of the Total Environment,2022,808:151866. doi: 10.1016/j.scitotenv.2021.151866
[15]	KIM K R, OWENS G, KWON S I, et al. Occurrence and environmental fate of veterinary antibiotics in the terrestrial environment[J]. Water, Air, & Soil Pollution,2011,214(1):163-174.
[16]	陈宇, 许亚男, 庞燕.抗生素赋存、来源及风险评估研究进展[J]. 环境工程技术学报,2021,11(3):562-570. CHEN Y, XU Y N, PANG Y. Advance in research on the occurrence, source and risk assessment of antibiotics[J]. Journal of Environmental Engineering Technology,2021,11(3):562-570.
[17]	HE S N, DONG D M, ZHANG X, et al. Occurrence and ecological risk assessment of 22 emerging contaminants in the Jilin Songhua River (Northeast China)[J]. Environmental Science and Pollution Research,2018,25(24):24003-24012. doi: 10.1007/s11356-018-2459-3
[18]	刘阳洋. 腐殖酸对海拉尔河典型抗生素污染物吸附作用研究[D]. 西安: 西安科技大学, 2017.
[19]	WANG L F, LI H, DANG J H, et al. Occurrence, distribution, and partitioning of antibiotics in surface water and sediment in a typical tributary of Yellow River, China[J]. Environmental Science and Pollution Research,2021,28(22):28207-28221. doi: 10.1007/s11356-021-12634-1
[20]	DAI G H, WANG B, HUANG J, et al. Occurrence and source apportionment of pharmaceuticals and personal care products in the Beiyun River of Beijing, China[J]. Chemosphere,2015,119:1033-1039. doi: 10.1016/j.chemosphere.2014.08.056
[21]	ZHANG P W, ZHOU H D, LI K, et al. Occurrence of pharmaceuticals and personal care products, and their associated environmental risks in a large shallow lake in North China[J]. Environmental Geochemistry and Health,2018,40(4):1525-1539. doi: 10.1007/s10653-018-0069-0
[22]	YANG L, WANG T Y, ZHOU Y Q, et al. Contamination, source and potential risks of pharmaceuticals and personal products (PPCPs) in Baiyangdian Basin, an intensive human intervention area, China[J]. Science of the Total Environment,2021,760:144080. doi: 10.1016/j.scitotenv.2020.144080
[23]	LI W H, GAO L H, SHI Y L, et al. Occurrence, distribution and risks of antibiotics in urban surface water in Beijing, China[J]. Environmental Science Processes & Impacts,2015,17(9):1611-1619.
[24]	吴颜岐, 宋帅, 史雅娟, 等.天津市地表水中新型优先污染物筛选与管控对策[J]. 环境科学,2022,43(8):4074-4086. WU Y Q, SONG S, SHI Y J, et al. Screening and control measures for new priority pollutants in surface water of Tianjin[J]. Environmental Science,2022,43(8):4074-4086.
[25]	CHEN K, ZHOU J L. Occurrence and behavior of antibiotics in water and sediments from the Huangpu River, Shanghai, China[J]. Chemosphere,2014,95:604-612. doi: 10.1016/j.chemosphere.2013.09.119
[26]	WU C X, HUANG X L, WITTER J D, et al. Occurrence of pharmaceuticals and personal care products and associated environmental risks in the central and Lower Yangtze River, China[J]. Ecotoxicology and Environmental Safety,2014,106:19-26. doi: 10.1016/j.ecoenv.2014.04.029
[27]	胡烨, 徐辉, 王殿常, 等.长江重点江段枯水期药物及个人护理品(PPCPs)的空间分布特征及来源[J]. 环境科学学报,2022,42(2):164-173. HU Y, XU H, WANG D C, et al. Spatial distribution and source of pharmaceuticals and personal care products in the dry season of the Yangtze River[J]. Acta Scientiae Circumstantiae,2022,42(2):164-173.
[28]	KONG M, XING L Q, YAN R M, et al. Spatiotemporal variations and ecological risks of typical antibiotics in rivers inflowing into Taihu Lake, China[J]. Journal of Environmental Management,2022,309:114699. doi: 10.1016/j.jenvman.2022.114699
[29]	严岩, 尤本胜, 刘伟京,等. 基于文献计量学的近20年水环境中抗生素污染研究趋势及热点分析[J/OL]. 环境工程技术学报, 2022. https://kns.cnki.net/kcms/detail/11.5972.X.20220908.1435.025.html. YAN Y, YOU B S, LIU W J, et al. Research trend and hot spot analysis of antibiotic pollution in water environment in recent 20 years based on bibiometrics[J/OL]. Journal of Environmental Engineering Technology, 2022. https://kns.cnki.net/kcms/detail/11.5972.X.20220908.1435.025.html.
[30]	CAO S S, DUAN Y P, TU Y J, et al. Pharmaceuticals and personal care products in a drinking water resource of Yangtze River Delta Ecology and Greenery Integration Development Demonstration Zone in China: occurrence and human health risk assessment[J]. Science of the Total Environment,2020,721:137624. doi: 10.1016/j.scitotenv.2020.137624
[31]	TANG J, SHI T Z, WU X W, et al. The occurrence and distribution of antibiotics in Lake Chaohu, China: seasonal variation, potential source and risk assessment[J]. Chemosphere,2015,122:154-161. doi: 10.1016/j.chemosphere.2014.11.032
[32]	DING H J, WU Y X, ZHANG W H, et al. Occurrence, distribution, and risk assessment of antibiotics in the surface water of Poyang Lake, the largest freshwater lake in China[J]. Chemosphere,2017,184:137-147. doi: 10.1016/j.chemosphere.2017.05.148
[33]	WANG Y Q, LIU Y, LU S Y, et al. Occurrence and ecological risk of pharmaceutical and personal care products in surface water of the Dongting Lake, China during rainstorm period[J]. Environmental Science and Pollution Research,2019,26(28):28796-28807. doi: 10.1007/s11356-019-06047-4
[34]	HU Y, YAN X, SHEN Y, et al. Antibiotics in surface water and sediments from Hanjiang River, Central China: occurrence, behavior and risk assessment[J]. Ecotoxicology and Environmental Safety,2018,157:150-158. doi: 10.1016/j.ecoenv.2018.03.083
[35]	WANG Z, DU Y, YANG C, et al. Occurrence and ecological hazard assessment of selected antibiotics in the surface waters in and around Lake Honghu, China[J]. Science of the Total Environment,2017,609:1423-1432. doi: 10.1016/j.scitotenv.2017.08.009
[36]	XIE H W, HAO H S, XU N, et al. Pharmaceuticals and personal care products in water, sediments, aquatic organisms, and fish feeds in the Pearl River Delta: occurrence, distribution, potential sources, and health risk assessment[J]. Science of the Total Environment,2019,659:230-239. doi: 10.1016/j.scitotenv.2018.12.222
[37]	PENG F J, PAN C G, ZHANG M, et al. Occurrence and ecological risk assessment of emerging organic chemicals in urban rivers: Guangzhou as a case study in China[J]. Science of the Total Environment,2017,589:46-55. doi: 10.1016/j.scitotenv.2017.02.200
[38]	任丙南, 耿静.三亚市水体中PPCPs的污染水平、分布特征及生态风险评价[J]. 环境科学,2021,42(10):4717-4726. REN B N, GENG J. Occurrence, distribution, and ecological risk assessment of pharmaceutical and personal care products in the aquatic environment of Sanya City, China[J]. Environmental Science,2021,42(10):4717-4726.
[39]	LIU S, WANG C, WANG P F, et al. Anthropogenic disturbances on distribution and sources of pharmaceuticals and personal care products throughout the Jinsha River Basin, China[J]. Environmental Research,2021,198:110449. doi: 10.1016/j.envres.2020.110449
[40]	FENG L, CHENG Y R, ZHANG Y Y, et al. Distribution and human health risk assessment of antibiotic residues in large-scale drinking water sources in Chongqing area of the Yangtze River[J]. Environmental Research,2020,185:109386. doi: 10.1016/j.envres.2020.109386
[41]	陈宇, 王涌涛, 黄天寅, 等.骆马湖水体中药品及个人护理品的污染特征及风险评估[J]. 环境科学研究,2021,34(4):902-909. CHEN Y, WANG Y T, HUANG T Y, et al. Pollution characteristics and risk assessment of pharmaceuticals and personal care products (PPCPs) in Luoma Lake[J]. Research of Environmental Sciences,2021,34(4):902-909.
[42]	李富娟.宁夏第三排水沟中典型PPCPs和PAHs的污染特征与生态风险评估[D]. 银川:宁夏大学, 2022.
[43]	雷晓宁. 新疆典型湖泊中抗生素的污染状况与分布特征[D]. 石河子: 石河子大学, 2014.
[44]	侯先宇, 高俊敏, 王德睿, 等.西藏申扎镇水土环境中抗生素的残留水平与分布特征[J]. 中国环境科学,2021,41(12):5849-5856. doi: 10.3969/j.issn.1000-6923.2021.12.041 HOU X Y, GAO J M, WANG D R, et al. Residue levels and distribution characteristics of antibiotics in the soil and water environment of Shenzha Town, Tibet[J]. China Environmental Science,2021,41(12):5849-5856. doi: 10.3969/j.issn.1000-6923.2021.12.041
[45]	WANG Y W, LI Y, HU A Y, et al. Monitoring, mass balance and fate of pharmaceuticals and personal care products in seven wastewater treatment plants in Xiamen City, China[J]. Journal of Hazardous Materials,2018,354:81-90. doi: 10.1016/j.jhazmat.2018.04.064
[46]	KIM H, HOMAN M. Evaluation of pharmaceuticals and personal care products (PPCPs) in drinking water originating from Lake Erie[J]. Journal of Great Lakes Research,2020,46(5):1321-1330. doi: 10.1016/j.jglr.2020.06.019
[47]	TAMTAM F, MERCIER F, Le BOT B, et al. Occurrence and fate of antibiotics in the Seine River in various hydrological conditions[J]. Science of the Total Environment,2008,393(1):84-95. doi: 10.1016/j.scitotenv.2007.12.009
[48]	BU Q W, WANG B, HUANG J, et al. Pharmaceuticals and personal care products in the aquatic environment in China: a review[J]. Journal of Hazardous Materials,2013,262:189-211. doi: 10.1016/j.jhazmat.2013.08.040
[49]	ZUCCATO E, CASTIGLIONI S, BAGNATI R, et al. Source, occurrence and fate of antibiotics in the Italian aquatic environment[J]. Journal of Hazardous Materials,2010,179(1/2/3):1042-1048.
[50]	GINEBREDA A, MUÑOZ I, de ALDA M L, et al. Environmental risk assessment of pharmaceuticals in rivers: relationships between hazard indexes and aquatic macroinvertebrate diversity indexes in the Llobregat River (NE Spain)[J]. Environment International,2010,36(2):153-162. doi: 10.1016/j.envint.2009.10.003
[51]	ZHANG S Y, ZHANG Q, DARISAW S, et al. Simultaneous quantification of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and pharmaceuticals and personal care products (PPCPs) in Mississippi River water, in New Orleans, Louisiana, USA[J]. Chemosphere,2007,66(6):1057-1069. doi: 10.1016/j.chemosphere.2006.06.067
[52]	SHARMA B M, BEČANOVÁ J, SCHERINGER M, et al. Health and ecological risk assessment of emerging contaminants (pharmaceuticals, personal care products, and artificial sweeteners) in surface and groundwater (drinking water) in the Ganges River Basin, India[J]. Science of the Total Environment,2019,646:1459-1467. doi: 10.1016/j.scitotenv.2018.07.235
[53]	SENGAR A, VIJAYANANDAN A. Human health and ecological risk assessment of 98 pharmaceuticals and personal care products (PPCPs) detected in Indian surface and wastewaters[J]. Science of the Total Environment,2022,807:150677. doi: 10.1016/j.scitotenv.2021.150677
[54]	吴天宇. 赤水河流域水体抗生素抗性基因赋存特征及来源解析[D]. 贵阳: 贵州大学, 2022.
[55]	孙钰, 梁一灿, 齐艳芬, 等.京津冀城市群生态效率的时序演进与空间分布特征[J]. 生态经济,2021,37(12):74-82. SUN Y, LIANG Y C, QI Y F, et al. Temporal evolution and spatial distribution characteristics of ecological efficiency in Beijing-Tianjin-Hebei urban agglomeration[J]. Ecological Economy,2021,37(12):74-82.
[56]	MONTES-GRAJALES D, FENNIX-AGUDELO M, MIRANDA-CASTRO W. Occurrence of personal care products as emerging chemicals of concern in water resources: a review[J]. Science of the Total Environment,2017,595:601-614. doi: 10.1016/j.scitotenv.2017.03.286
[57]	ROSSI R, SALUTI G, MORETTI S, et al. Multiclass methods for the analysis of antibiotic residues in milk by liquid chromatography coupled to mass spectrometry: a review[J]. Food Additives & Contaminants Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment,2018,35(2):241-257.
[58]	BAI Y W, MENG W, XU J, et al. Occurrence, distribution and bioaccumulation of antibiotics in the Liao River Basin in China[J]. Environmental Science Processes & Impacts,2014,16(3):586-593.
[59]	张盼伟.海河流域典型水体中PPCPs的环境行为及潜在风险研究[D]. 北京: 中国水利水电科学研究院, 2018.
[60]	陈宇, 许亚南, 项颂, 等.骆马湖表层沉积物中PPCPs的赋存特征及生态风险评估[J]. 环境科学研究,2021,34(8):1835-1843. CHEN Y, XU Y N, XIANG S, et al. Characteristics and ecological risk assessment of PPCPs in surface sediments of Luoma Lake[J]. Research of Environmental Sciences,2021,34(8):1835-1843.
[61]	张盼伟, 周怀东, 赵高峰, 等.太湖表层沉积物中PPCPs的时空分布特征及潜在风险[J]. 环境科学,2016,37(9):3348-3355. ZHANG P W, ZHOU H D, ZHAO G F, et al. Spatial, temporal distribution characteristics and potential risk of PPCPs in surface sediments from Taihu Lake[J]. Environmental Science,2016,37(9):3348-3355.
[62]	杨俊, 王汉欣, 吴韵斐, 等.苏州市水环境中典型抗生素污染特征及生态风险评估[J]. 生态环境学报,2019,28(2):359-368. YANG J, WANG H X, WU Y F, et al. Occurrence, distribution and risk assessment of typical antibiotics in the aquatic environment of Suzhou City[J]. Ecology and Environmental Sciences,2019,28(2):359-368.
[63]	高月, 李杰, 许楠, 等.汉江水相和沉积物中药品和个人护理品(PPCPs)的污染水平与生态风险[J]. 环境化学,2018,37(8):1706-1719. doi: 10.7524/j.issn.0254-6108.2018022604 GAO Y, LI J, XU N, et al. Pollution levels and ecological risks of PPCPs in water and sediment samples of Hanjiang River[J]. Environmental Chemistry,2018,37(8):1706-1719. doi: 10.7524/j.issn.0254-6108.2018022604
[64]	CUI Y F, WANG Y H, PAN C G, et al. Spatiotemporal distributions, source apportionment and potential risks of 15 pharmaceuticals and personal care products (PPCPs) in Qinzhou Bay, South China[J]. Marine Pollution Bulletin,2019,141:104-111. doi: 10.1016/j.marpolbul.2019.02.012
[65]	FISS E M, RULE K L, VIKESLAND P J. Formation of chloroform and other chlorinated byproducts by chlorination of triclosan-containing antibacterial products[J]. Environmental Science & Technology,2007,41(7):2387-2394.
[66]	LIU Y W, LI X, TAN Z, et al. Inhibition of tetracycline on anaerobic digestion of swine wastewater[J]. Bioresource Technology,2021,334:125253. doi: 10.1016/j.biortech.2021.125253
[67]	ZHANG L L, QIN S, SHEN L N, et al. Bioaccumulation, trophic transfer, and human health risk of quinolones antibiotics in the benthic food web from a macrophyte-dominated shallow lake, North China[J]. Science of the Total Environment,2020,712:136557. doi: 10.1016/j.scitotenv.2020.136557
[68]	FERGUSON P J, BERNOT M J, DOLL J C, et al. Detection of pharmaceuticals and personal care products (PPCPs) in near-shore habitats of southern Lake Michigan[J]. Science of the Total Environment,2013,458/459/460:187-196.
[69]	LONG E R, DUTCH M, WEAKLAND S, et al. Quantification of pharmaceuticals, personal care products, and perfluoroalkyl substances in the marine sediments of Puget Sound, Washington, USA[J]. Environmental Toxicology and Chemistry,2013,32(8):1701-1710. doi: 10.1002/etc.2281
[70]	TOGOLA A, BUDZINSKI H. Multi-residue analysis of pharmaceutical compounds in aqueous samples[J]. Journal of Chromatography A,2008,1177(1):150-158. doi: 10.1016/j.chroma.2007.10.105
[71]	KLOSTERHAUS S L, GRACE R, HAMILTON M C, et al. Method validation and reconnaissance of pharmaceuticals, personal care products, and alkylphenols in surface waters, sediments, and mussels in an urban estuary[J]. Environment International,2013,54:92-99. doi: 10.1016/j.envint.2013.01.009
[72]	RAMASWAMY B R, SHANMUGAM G, VELU G, et al. GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian Rivers[J]. Journal of Hazardous Materials,2011,186(2/3):1586-1593.
[73]	MARTÍN J, SANTOS J L, APARICIO I, et al. Multi-residue method for the analysis of pharmaceutical compounds in sewage sludge, compost and sediments by sonication-assisted extraction and LC determination[J]. Journal of Separation Science,2010,33(12):1760-1766. doi: 10.1002/jssc.200900873
[74]	BERETTA M, BRITTO V, TAVARES T M, et al. Occurrence of pharmaceutical and personal care products (PPCPs) in marine sediments in the Todos os Santos Bay and the north coast of Salvador, Bahia, Brazil[J]. Journal of Soils and Sediments,2014,14(7):1278-1286. doi: 10.1007/s11368-014-0884-6
[75]	ZHANG J Q, DONG Y H. Effect of low-molecular-weight organic acids on the adsorption of norfloxacin in typical variable charge soils of China[J]. Journal of Hazardous Materials,2008,151(2/3):833-839.
[76]	VAZQUEZ-ROIG P, SEGARRA R, BLASCO C, et al. Determination of pharmaceuticals in soils and sediments by pressurized liquid extraction and liquid chromatography tandem mass spectrometry[J]. Journal of Chromatography A,2010,1217(16):2471-2483. doi: 10.1016/j.chroma.2009.11.033
[77]	潘寻, 苏都, 宋光明, 等.围场县农田典型药物和个人护理品污染特征与生态风险预评价[J]. 生态毒理学报,2017,12(5):184-192. doi: 10.7524/AJE.1673-5897.20170620001 PAN X, SU D, SONG G M, et al. Pollution characteristics and ecological risk pre-assessment of pharmaceuticals and personal care products in cropland of Weichang County[J]. Asian Journal of Ecotoxicology,2017,12(5):184-192. doi: 10.7524/AJE.1673-5897.20170620001
[78]	CHEN H, LIU S, XU X R, et al. Antibiotics in the coastal environment of the Hailing Bay region, South China Sea: spatial distribution, source analysis and ecological risks[J]. Marine Pollution Bulletin,2015,95(1):365-373. doi: 10.1016/j.marpolbul.2015.04.025
[79]	ZHAO S N, LIU X H, CHENG D M, et al. Temporal-spatial variation and partitioning prediction of antibiotics in surface water and sediments from the intertidal zones of the Yellow River Delta, China[J]. Science of the Total Environment,2016,569/570:1350-1358. doi: 10.1016/j.scitotenv.2016.06.216
[80]	刘兴华. 黄河三角洲滨海土壤和沉积物颗粒态有机质特性及其对抗生素吸附作用研究[D]. 烟台:中国科学院大学(中国科学院烟台海岸带研究所), 2018.
[81]	SASSMAN S A, LEE L S. Sorption of three tetracyclines by several soils: assessing the role of pH and cation exchange[J]. Environmental Science & Technology,2005,39(19):7452-7459.
[82]	KAHLE M, STAMM C. Sorption of the veterinary antimicrobial sulfathiazole to organic materials of different origin[J]. Environmental Science & Technology,2007,41(1):132-138.
[83]	LI J Y, ZHANG Y S, KATSEV S. Phosphorus recycling in deeply oxygenated sediments in Lake Superior controlled by organic matter mineralization[J]. Limnology and Oceanography,2018,63(3):1372-1385. doi: 10.1002/lno.10778
[84]	FIGUEROA R A, LEONARD A, MacKAY A A. Modeling tetracycline antibiotic sorption to clays[J]. Environmental Science & Technology,2004,38(2):476-483.
[85]	WANG Y J, JIA D A, SUN R J, et al. Adsorption and cosorption of tetracycline and copper(Ⅱ) on montmorillonite as affected by solution pH[J]. Environmental Science & Technology,2008,42(9):3254-3259.
[86]	李宗宸, 魏群山, 罗专溪, 等.九龙江沉积物主要组分对四环素类抗生素吸附性能对比[J]. 生态环境学报,2016,25(10):1714-1720. LI Z C, WEI Q S, LUO Z X, et al. Comparison of the performances of major components of the surface sediment from Jiulong River to tetracyclines adsorption[J]. Ecology and Environmental Sciences,2016,25(10):1714-1720.
[87]	ZHANG G D, LIU X H, LU S Y, et al. Occurrence of typical antibiotics in Nansi Lake's inflowing rivers and antibiotic source contribution to Nansi Lake based on principal component analysis-multiple linear regression model[J]. Chemosphere,2020,242:125269. doi: 10.1016/j.chemosphere.2019.125269
[88]	XU J, ZHANG Y, ZHOU C B, et al. Distribution, sources and composition of antibiotics in sediment, overlying water and pore water from Taihu Lake, China[J]. Science of the Total Environment,2014,497/498:267-273. doi: 10.1016/j.scitotenv.2014.07.114
[89]	HEBIG K H, GROZA L G, SABOURIN M J, et al. Transport behavior of the pharmaceutical compounds carbamazepine, sulfamethoxazole, gemfibrozil, ibuprofen, and naproxen, and the lifestyle drug caffeine, in saturated laboratory columns[J]. Science of the Total Environment,2017,590/591:708-719. doi: 10.1016/j.scitotenv.2017.03.031
[90]	WANG J T, HU J, ZHANG S W. Studies on the sorption of tetracycline onto clays and marine sediment from seawater[J]. Journal of Colloid and Interface Science,2010,349(2):578-582. doi: 10.1016/j.jcis.2010.04.081
[91]	FAIRBAIRN D J, KARPUZCU M E, ARNOLD W A, et al. Sediment-water distribution of contaminants of emerging concern in a mixed use watershed[J]. Science of the Total Environment,2015,505:896-904. doi: 10.1016/j.scitotenv.2014.10.046
[92]	SCHAFFER M, BOXBERGER N, BÖRNICK H, et al. Sorption influenced transport of ionizable pharmaceuticals onto a natural sandy aquifer sediment at different pH[J]. Chemosphere,2012,87(5):513-520. doi: 10.1016/j.chemosphere.2011.12.053
[93]	吴志坚, 刘海宁, 张慧芳.离子强度对吸附影响机理的研究进展[J]. 环境化学,2010,29(6):997-1003. WU Z J, LIU H N, ZHANG H F. Research progress on mechanisms about the effect of ionic strength on adsorption[J]. Environmental Chemistry,2010,29(6):997-1003.
[94]	杨宇轩, 徐瑞皎, 冯启言, 等.3种喹诺酮类抗生素在骆马湖饮用水源地沉积物上的吸附特征[J]. 环境污染与防治,2020,42(6):717-722. YANG Y X, XU R J, FENG Q Y, et al. Adsorption characteristics of three quinolone antibiotics on sediment from drinking water source of Luoma Lake[J]. Environmental Pollution & Control,2020,42(6):717-722.
[95]	BRILLAULT J, TEWES F, COUET W, et al. In vitro biopharmaceutical evaluation of ciprofloxacin/metal cation complexes for pulmonary administration[J]. European Journal of Pharmaceutical Sciences,2017,97:92-98. doi: 10.1016/j.ejps.2016.11.011
[96]	庞会玲, 杨桂朋, 高先池, 等.pH及表面活性剂对诺氟沙星在海洋沉积物上吸附行为的影响[J]. 环境科学,2012,33(1):129-134. PANG H L, YANG G P, GAO X C, et al. Impacts of pH and surfactants on adsorption behaviors of norfloxacin on marine sediments[J]. Environmental Science,2012,33(1):129-134.
[97]	钟振兴. 磺胺抗生素在湖泊沉积物中的吸附和降解行为研究[D]. 重庆: 西南大学, 2012.
[98]	JE C H, HAYES D F, KIM K S. Simulation of resuspended sediments resulting from dredging operations by a numerical flocculent transport model[J]. Chemosphere,2007,70(2):187-195. doi: 10.1016/j.chemosphere.2007.06.033
[99]	CHEN Q W, GUO X, HUA G F, et al. Migration and degradation of swine farm tetracyclines at the river catchment scale: can the multi-pond system mitigate pollution risk to receiving rivers[J]. Environmental Pollution,2017,220:1301-1310. doi: 10.1016/j.envpol.2016.11.004
[100]	LI S, HUANG Z, WANG Y, et al. Migration of two antibiotics during resuspension under simulated wind-wave disturbances in a water-sediment system[J]. Chemosphere,2018,192:234-243. ◇ doi: 10.1016/j.chemosphere.2017.10.131