TCDD和汞、镉、铅、砷联合毒性效应及机理研究进展

张元元; 郭少娟; 王菲菲; 杨立新

doi:10.12153/j.issn.1674-991X.20200217

TCDD和汞、镉、铅、砷联合毒性效应及机理研究进展

doi: 10.12153/j.issn.1674-991X.20200217

环境基准与风险评估国家重点实验室,中国环境科学研究院

详细信息

作者简介:
张元元(1996—),女,硕士研究生,研究方向为分子毒理学, jenella0804@163.com

通讯作者:
杨立新 E-mail: yanglx@craes.org.cn

中图分类号: X171.5
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- 文章访问数: 383
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- PDF下载量: 97
- 被引次数: 0
出版历程
- 收稿日期: 2020-09-01
- 刊出日期: 2021-03-20

Research progress on joint toxic effects and mechanisms of the mixture of TCDD and mercury, cadmium, lead, arsenic

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences

More Information

Corresponding author: YANG Lixin E-mail: yanglx@craes.org.cn

摘要

摘要: 化学污染物通常以混合物的形式存在,其中重金属和有机化学物质是环境中常见的两大类污染物,它们的毒性效应长期受到关注。由于化学污染物混合物毒性效应的复杂性和研究方法的限制,现有研究大多关注污染物单一毒性效应和同一类化学污染物联合毒性效应,而对不同类型化学污染物联合毒性效应研究甚少。在系统分析、总结2,3,7,8-四氯代二苯并二英(TCDD)和汞、镉、铅、砷的环境来源、环境浓度、单一及联合毒性效应和分子机理研究的基础上,结合对单一和混合物诱导表达基因的转录组分析,基因表达水平的定量研究以及代谢组学、暴露组学等技术在联合毒性效应与机理研究中的应用前景,提出基于特异性基因表达水平来研究、评价联合毒性效应的方法。
- TCDD /
- 汞 /
- 镉 /
- 铅 /
- 砷 /
- 联合暴露 /
- 毒性效应 /
- 机理
Abstract: Chemicals usually exist in the environment in the form of mixtures. Heavy metals and organic chemicals are two kinds of common pollutants in the environment, and their toxic effects have been concerned for a long time. Considering the complexity of toxic effects of chemicals mixtures and the limitation of risk assessment methods, most of the existing studies focus mainly on the toxic effects of single chemicals or a group of chemicals, but few on the joint toxic effects of different types of chemical pollutants. A number of studies related to environmental sources, concentrations, single and joint toxic effects and molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-dioxins (TCDD), mercury, cadmium, lead and arsenic were analyzed and summarized systematically. Combined with a transcriptome analysis of single and mixed induced expression genes, a quantitative study of gene expression level, and the application prospect of metabolomics and exposure omics and other technologies in the study of joint toxic effects and mechanisms, a method based on specific gene expression level was proposed to study and assess the joint toxic effects.
- TCCD /
- mercury /
- cadmium /
- lead /
- arsenic /
- combined exposure /
- toxic effect /
- mechanism

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