Abstract: The ultrasound (US) -Fenton-like system was used to treat the simulated wastewater solution of dye (methyl violet 6B). An ultrasonically enhanced multi-metal synergistic Fenton-like system was constructed to efficiently degrade the simulated wastewater solution of methyl violet 6B, revealing the relationship of synergistic effects between ultrasound and metal ions. The key parameters (the dosages of H₂O₂, Fe²⁺, Cu²⁺ and Mn²⁺) were optimized by using the Box-Behnken response surface method. The single-factor experimental study found that the combination of ultrasound and Fenton (or Fenton-like) reaction had a good synergistic effect. A regression model of influencing factors was established based on the response surface analysis. The results showed that the ultrasonic-Fenton/Fenton-like process could accelerate the degradation of dye simulated wastewater. The predicted optimal conditions were as follows: the dosage of H₂O₂ was 17.1 mg·L^-1, the dosage of Fe²⁺ was 26.6 mg·L^-1, the dosage of Cu²⁺ was 3.6 mg·L^-1, and the dosage of Mn²⁺ was 7.6 mg·L^-1. The average removal rate of the verification experiment was 99.74%, which was close to the predicted value of the model. Therefore, this process could provide basic experimental data and technical reference for the treatment of organic dye wastewater.