Abstract: The water environmental problems caused by industrial pollution were serious in Liao River Basin. The pollution problems in different areas of the watershed were related with industries in the areas and the type and concentration of pollutants had obvious industry characteristic. There are a great variety of water treatment technologies; however, different water treatment technologies have obviously different treatment effects for wastewater with different characteristics. Considering that the application scope of water treatment technologies was different and the wastewater had obvious industrial characteristics, multiple-index comprehensive assessment research was performed to find out the optimal technologies for different industries by considering pollutant reduction effect, treatment efficiency and economic factors in order to realize rational allocation of technologies, using the methods such as fuzzy and grey integrated evaluation method and analytic hierarchy process(AHP) method. Because the assessment processes involved both complex mathematic models and big calculation task, the assessment efficiency was not high, and the accuracy was very difficult to guarantee. An assessment software for water pollution treatment technologies was thus developed. The design principles, structure, functions as well as application cases of the software were introduced. The results showed that the application of this software could significantly improve the assessment efficiency and accuracy for water pollution treatment technologies.